Key Findings - Estimated Minimum Lethal Dose of Fluoride:
1) The currently accepted estimate for the minimum lethal dose of fluoride is 5 mg/kg (i.e. 5 milligrams of fluoride for each kilogram of bodyweight). This dose is referred to in the medical literature as the "Probably Toxic Dose" or "PTD." It is sufficient to produce severe poisoning, including death, in some individuals.
2) All fluoride toothpastes sold in the United States, including flavored toothpastes specifically marketed to children, contain the minimum lethal dose of fluoride.
3) Each year there are thousands of reports to Poison Control centers in the United States related to excessive ingestion of fluoride dental products (toothpaste, mouthrinses, and supplements).
4) Early symptoms of acute fluoride toxicity (e.g. gastrointestinal pain, nausea, vomiting, excess salivation, fever) can be produced at doses well below 5 mg/kg - at doses as low as 0.1 to 0.3 mg/kg. These symptoms are responsible for many of the calls to Poison Control.
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